Globular glial tauopathies (GGT): consensus recommendations
نویسندگان
چکیده
منابع مشابه
Glial Tau Pathology in Tauopathies: Functional Consequences.
Tauopathies are a class of neurodegenerative diseases characterized by the presence of hyperphosphorylated and aggregated tau pathology in neuronal and glial cells. Though the ratio of neuronal and glial tau aggregates varies across diseases, glial tau aggregates can populate the same degenerating brain regions as neuronal tau aggregates. While much is known about the deleterious consequences o...
متن کاملExpanding the phenotypic associations of globular glial tau subtypes
INTRODUCTION Clinicopathologic correlation in non-Alzheimer's tauopathies is variable, despite refinement of pathologic diagnostic criteria. In the present study, the clinical and neuroimaging characteristics of globular glial tauopathy (GGT) were examined to determine whether subtyping according to consensus guidelines improves clinicopathologic correlation. METHODS Confirmed GGT cases (n = ...
متن کاملTemporal Variant Frontotemporal Dementia Is Associated with Globular Glial Tauopathy
Frontotemporal dementia (FTD) is a clinically and pathologically heterogeneous neurodegenerative disorder associated with atrophy of the frontal and temporal lobes. Most patients with focal temporal lobe atrophy present with either the semantic dementia subtype of FTD or the behavioral variant subtype. For patients with temporal variant FTD, the most common cause found on post-mortem examinatio...
متن کاملGlobular Glial Tauopathy Presenting as Semantic Variant Primary Progressive Aphasia.
Report of aCase |Theclinical, neuropsychometric, and imaging featuresof this casepreviouslywere reported in2008.2Briefly, awoman in her 60swas referred to the Behavioral Neurology Clinic formemory loss, characterizedbydifficulty rememberingnames.Longitudinal evaluations revealedprogressiveanomia with loss of word knowledge, prosopagnosia, and surface dyslexia. Her last completed neuropsychometr...
متن کاملTransgenic Mouse Model of Tauopathies with Glial Pathology and Nervous System Degeneration
Frontotemporal dementias (FTDs), including corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), are neurodegenerative tauopathies characterized by widespread CNS neuronal and glial tau pathologies, but there are no tau transgenic (Tg) mice that model neurodegeneration with glia tau lesions. Thus, we generated Tg mice overexpressing human tau in neurons and glia. No neuronal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2013
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-013-1171-0